The health effects of hot chili peppers in our diet have been debated for some time and numerous biomedical studies have been carried out regarding this topic. Many results are favorable even if there are some contraindications that have often been questioned by the majority of experts.
Not only has the antibacterial role of hot chili peppers been
ascertained but also its high vitamin-C content antioxidant power, and positive
digestive effect—to mention just some of its properties. In early 2015, the use
of hot chili peppers as a painkiller was authoritatively confirmed. As is
well-known, hot chili peppers owe this effect to the presence in their fruit
-unique in the vegetable world - of an alkaloid called capsaicin, a substance
that “cheats” the TRPV1 receptor by making us feel a high temperature and therefore
a strong burning sensation.
In February 2015, Science Signaling*, a scientific journal of
the American Society for the Advancement of Science (AAAS), published an
article on how this alkaloid works reporting the results of a carefully
researched study carried out by a group of scientists from the Rutgers
University Medical School (New Jersey). This substance has numerous properties
often beneficial to human health. Specifically, capsaicin’s pain-relief action
was analyzed, which takes place by inactivating the mechanosensitive channels
found in the neuronal membranes.
For a long time, it had been observed that, as a topical pain
medication, capsaicin caused numbness in the tissue. However, researchers had
never been able to understand how that effect was obtained. Now we know that
the initial attenuation of pain is the consequence of capsaicin activating a
vanilloid receptor’s (TRPV1) ion channels in the sensory neurons. It is
interesting to observe that the term “vanilloid” derives from the sensitivity
of those receptors reacting to all substances having a vanillic functional
group (vanillin is the one that gives vanilla its characteristic smell) which
is also precisely that of capsaicin, closely correlated structurally to
vanillin.
The final result is that prolonged stimulus with capsaicin
desensitizes these neurons. The importance of this research carried out by the
New Jersey group lies in having discovered the link between capsaicin’s
heat-stimulating function (which everyone experiences when eating a hot chili
pepper) and its ability to relieve neuralgic, neuropathic and muscle pain.
Essentially, the activation of the TRPV1 receptor involves, in its
turn, the (almost 100%) inhibition of other ion channels in the neuronal
membrane, causing the attenuation of the above-mentioned conditions. What is
unique in this study is how the biochemical processes that take place in one
kind of channel regulate the activity of a different kind of ion channel. In
other words, it is a cross-talk, i.e., an unusual “molecular dialogue”, between
ion channels, mediated by specific molecules, phospholipids, which this same
study also identified.
Despite using terms unfamiliar to most people, I hope it can be
understood how the studies being carried out on hot chili peppers are able to
give us increasingly more scientific explanations on this special vegetable’s
various positive roles for our well-being.
*"Borbiro I. et al., Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Science Signalling, doi:10.1126/scisignal.2005667,2015
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