BLUEBERRY fruit extracts reduce ovarian damage caused by subchronic cadmium exposure - Extractos de frutos de ARÁNDANO reducen el daño ovárico causado por exposición subcrónica al cadmio

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Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. Researchers in Brazil verified the effect of cadmium exposure on the ovaries of mice and the blueberry (Vaccinium ashei) extract as a potential therapy. Blueberry therapy was effective in restoring reactive species levels and δ-aminolevulinate dehydratase activity, and partially improved the viability of cadmium-disrupted follicles. This therapy was not able to restore the 17 β-hydroxysteroid dehydrogenase activity. Extract HPLC evaluation indicated the presence of quercetin, quercitrin, isoquercetin, and ascorbic acid. Ascorbic acid was the major substance and its concentration was 620.24 µg/mL. Thus, cadmium accumulates in the ovaries of mice after subchronic exposure, inducing cellular damage, and the blueberry extract possesses antioxidant properties that could protect, at least in part, the ovarian tissue from cadmium toxicity. 

Source: A Pinto Izaguirry, M Bucco Soares, L Musacchio Vargas, C Chiapinotto Spiazzi, D dos Santos Brum, S Noremberg, AS Loureiro Mendez, F Weber Santos. Wiley Periodicals, Inc. Environ Toxicol, 2015.